Bills at 49ers Odds | The biggest question swirling around this week’s installment of Sunday Night Football is the health of San Francisco 49ers quarterback Brock Purdy.
He missed an NFL game for the first time in his career due to a shoulder injury last week, and the 49ers’ trip to Lambeau Field did not go well – the Packers rolled over San Francisco, 38-10.
That was the Niners’ largest margin of defeat since 2018, when they lost to the L.A. Rams, 39-10, in Week 9. The 49ers only managed 241 yards of offense against Green Bay – not a team known for stifling defense.
The 49ers turned the ball over three times with backup quarterback Brandon Allen at the helm.
This week, they face a Buffalo team riding in on a six-game winning streak and fresh from their bye week.
At this writing, all we know is that Purdy remains questionable for Sunday. He faced limits in practice on Wednesday, just like last week, and he ended up sitting out for Sunday’s game.
In offensive warmups, he just threw the ball twice – a short toss to Kyle Juszczyk during the running back drill and an even shorter toss to the equipment staff.
He hasn’t had an injury since the 2023 NFC Championship game, when he tore his UCL in his throwing arm and only ended up attempting four passes.
Your sports betting choices for this game will likely keep Purdy’s status in mind. Our assumptions are that Purdy will play, so you’ll want to weigh that as you make your choice.
SNF Bills at 49ers Odds: NFL Game Lines in Week 13 | NFL 2024/25 Season
Opening SNF Game Odds Subject to Change: San Francisco +7 / O/U 43.5
When: Sunday, December 1, 2024, 8:20 pm ET
Where: Highmark Stadium, Orchard Park, NY
TV: NBC
Radio: Westwood One
Live Stream: Peacock
San Francisco 49ers SNF Line +270
The 49ers sit at 5-6 heading east, and even though the NFC West is tight, they’ve caused themselves some problems by losing at home to Arizona and Seattle. They’re only one game out of the division lead, but those tiebreaker problems make winning every week even more important. Even with the return of Christian McCaffrey to the offense, the 49ers haven’t shown that knockout capacity that they have in recent years.
In addition to Purdy, they didn’t have edge rusher Nick Bosa (oblique) or left tackle Trent Williams (ankle). They are also listed as questionable for the Buffalo game; if it comes out that these two starters will also be out, the line could continue to grow. However, Brandon Allen isn’t your timid backup. He had passes that were on target and on time when he had time in the pocket. The problems came from too many penalties, receivers dropping passes, and players putting the ball on the grass.
McCaffrey has played in three games since returning from a lengthy absence due to a calf injury. Through three games, he has only run for a combined total of 149 yards, well below his usual average. His game high (79 yards) came against Seattle. Tailback Jordan Mason has run the ball well in McCaffrey’s place, picking up 711 yards and scoring three times, so expect him to get carries as well.
Interestingly, the top pass catcher has been tight end George Kittle (49 receptions, 642 yards, 8 TD). That shows you how much the passing offense has suffered with the loss of wide receiver Brandon Aiyuk for the season and the periodic absences of Deebo Samuel. The offense has been just above average, scoring 23.6 points per game, good for 13th in the league. On defense, they rank 21st, permitting 23.6 points per game. Their top tackler has been linebacker Fred Warner (84), who also has two of the 11 interceptions the team has posted. Defensive end Leonard Floyd leads the team in sacks, with 6.5 of the 28 San Francisco sacks.
^Buffalo Bills SNF Line -340
The Bills have had the week to heal up and get refreshed after their big home win over Kansas City. They were able to hang 30 on a Chiefs team that hadn’t allowed that many points since Week 4 of the 2022 season. Patrick Mahomes hasn’t really had to play from behind much this season, but the added urgency to the passing game led to Mahomes throwing a pair of picks.
This win kept Buffalo in contention for the top seed in the AFC, giving them even more motivation coming in this week. There’s also Josh Allen’s MVP-level play this season. In previous years, the problems have had to do with ball security, but an improved rushing offense has taken pressure off his shoulders. Allen put the game on ice with a 26-yard touchdown run that came on a fourth-and-2 in the late minutes. That was the second-longest rushing touchdown of his career, but he has had James Cook and Ray Davis taking a lot of the rushing burden off his shoulders.
Buffalo has a perfect 5-0 home record; their road losses came at Houston and at Baltimore (the latter of these coming as the Bills’ only rout loss of the year). The Buffalo offense ranks third in scoring (29.1 points per game), almost a touchdown per game more than San Francisco. Their defense only permits 19.5 points per game, which ranks seventh in the league. Their top tackler is linebacker Dorian Williams (97). Edge rusher Greg Rosseau leads the team in sacks (5.5 out of the team’s total of 27. They’ve picked off 13 passes on the year, with six players each kicking in two picks, including safety Damar Hamlin.
^Bills at 49ers Odds, Final Score and Prediction in Week 13
In addition to Purdy, Williams and Bosa, other 49ers listed as questionable are wide receiver Chris Conley, defensive tackle Kevin Givens, and cornerback Deommodore Lenoir. The Bills only have two players listed as questionable: wide receiver Keon Coleman and tight end Dalton Kincaid.
Even if Brock Purdy is healthy, there have just been too many injuries for San Francisco to handle. Christian McCaffrey is back on the field, but he’s clearly not ready to produce at the level that he has shown in the past. He’s still looking for his first touchdown of 2024 after establishing himself as a touchdown generator in the past. While Brandon Allen played well, the team didn’t look solid at all under his leadership. Even if Trent Williams can play, the Bills will be able to pressure the quarterback.
For a quick look at the numbers, Buffalo has a 12-game home winning streak against teams entering on a losing streak. The 49ers have gone just 1-8 against the spread in their last nine games against teams above .500. In the last five games when the 49ers have been underdogs, they have lost the first half four times, and while Buffalo has started key games slowly in the past, once they get things going in the right direction, they haven’t been a team susceptible to late collapses.
With or without Purdy, the Bills should cover this seven-point spread. I’m assuming that he will play just because the 49ers can ill afford another loss, and he gives the team a better shot than Allen does.
I predict a final score of Buffalo 30, San Francisco 20.
^A look at the current records & standings headed into #NFLThanksgiving 👀 pic.twitter.com/Ew6mhmpH3R
— OutOfSightSports🚀™️ (@OOSSports) November 27, 2024
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