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Let’s take a look at the CONCACAF Champions Cup odds, quarterfinal schedule, as well as each team’s chances to win the whole thing, as you plan for your soccer sports betting this week.
We’ve had a couple of weeks since the round of 16 of the CONCACAF Champions Cup, but now that the international break is over, it’s time for the quarterfinals. MLS has four teams left, the same number as Liga MX.
CONCACAF Champions Cup Odds, Betting Quarterfinals, Leg 1 Schedule with Predictions
The quarterfinals consist of two legs, and now that we’re down to the last eight, the Cinderella teams have all been sent home.
All eight remaining teams have made deep runs in this tournament before, and each of them would love to add this cup to their trophy racks.
Club America (+113) vs Cruz Azul (+232) (Draw +244)
When: Tuesday, April 1, 9:15 pm ET
Champions Cup Pick: Take the draw
These teams also squared off in the semifinals of Liga MX’s Apertura playoffs in December. Club America picked up a 4-3 nailbiter on aggregate. They also look like a smart pick in the 2025 Clausura season after rolling over Tigres UANL, 3-0, on Saturday. They have a six-match unbeaten streak in Liga MX play (4 wins, 2 draws) since they lost to Club Necaxa, 3-2, in February. Club America already sent one Liga MX side home in the round of 16 after stopping Guadalajara, 4-1, on aggregate.
Cruz Azul have their offense rolling in the knockout rounds. In the round of 32, they routed Haitian side Real Hope, 7-0, and then they stopped the Seattle Sounders, 4-1, on aggregate in the round of 16. They beat Guadalajara, 1-0, in Liga MX play on Saturday and are in fifth in the Clausura table – but just five points back of first-place Club America. A win here would make a significant statement. Club America have just lost once in their last eight home matches, with five wins and two draws. However, Cruz Azul have just lost once in their last 15 matches, home and away, across all competitions, with 10 wins and four draws.
^LA Galaxy (+165) vs Tigres UANL (+155) (Draw +244)
When: Tuesday, April 1, 11:15 pm ET
Champions Cup Pick: Tigres UANL to win
LA Galaxy’s struggles in 2025 continue. In MLS, they have yet to win a match in six tries (two draws and four losses). They lost to Orlando City SC on Sunday, 2-1, and now they have permitted 12 goals while scoring just five. In the CONCACAF Champions Cup round of 16, they took on Costa Rican side Herediano and advanced, 4-2, on aggregate.
Tigres UANL look to bounce back from that 3-0 whipping they took from Club America on Saturday. That ended a three-match winning streak in Liga MX play in which they scored six goals while posting two clean sheets. They narrowly beat Real Esteli in the round of 32 and then sent MLS team FC Cincinnati home in the round of 16, winning, 4-2 on aggregate. Given the struggles that LA Galaxy have shown when playing quality opposition, this is frankly a surprising moneyline.
^Vancouver Whitecaps (-103) vs Pumas UNAM (+265) (Draw +260)
When: Wednesday, April 2, 9:30 pm ET
Champions Cup Pick: Vancouver to win
Vancouver is the unlikely leaders in the MLS Western Conference table after posting 13 points in six games. They show an intrepid defense, solid chemistry, and real finishing ability. They beat Monterrey away, tied them at home, and advanced on the strength of away goals. With Ryan Gauld on the shelf, the offense is starting to take on water, but Brian White has stepped in, with three goals in four matches.
Pumas are one of the storied teams in Liga MX, with seven league titles and a roster filled with talent. However, they are just in 10th place in the Clausura table, taking 17 points out of 13 games. They did stop LD Alajuelense, 3-1, on aggregate in the CONCACAF Champions Cup Round of 16, and they did stop third-place Leon in Liga MX play this weekend. Those are signs that Pumas could be rounding back into form, but Vancouver has earned respect in this home fixture.
^CONCACAF Champions Cup Odds provided by Xbet
LAFC (+149) vs Inter Miami (+171) (Draw +246)
When: Wednesday, April 2, 11:30 pm ET
Champions Cup Pick: Take the draw
Inter Miami decisively defeated Jamaican side Cavalier 4-0 on aggregate in the round of 16, clinching both matches 2-0 without Lionel Messi. In March, they enjoyed a perfect record, winning all six competitive fixtures and earning points in eight of their last nine games, with the only blemish being a 2-2 draw against New York City FC. Last year, they exited the quarterfinals to Monterrey but have never lost a CONCACAF Champions Cup tie against MLS teams, having also eliminated Sporting Kansas City and Nashville SC.
LAFC sent Columbus Crew home in the round of 16, winning 4-2 on aggregate. That was particularly satisfying as the Crew sent LAFC home from the last Leagues Cup and kept them from winning their second straight MLS Cup in 2023. However, in MLS play, LAFC have dropped four of five, including a 3-2 home loss to San Diego FC on Saturday. They have yet to lose at home in CONCACAF Champions Cup play. They have a 2-1 all-time record against Inter Miami, although they haven’t beaten them at home since 2020.
^Quarterfinals Power Rankings
8. LA Galaxy
In 2025, the LA Galaxy became the first reigning MLS Cup champion to start a season with six winless matches. Lacking roster strength, chemistry, and health, the team’s chances for success seem bleak, raising doubts about their dignity in the quarterfinals.
7. LAFC
The Black and Gold come in the wake of a 3-2 loss to MLS expansion team San Diego FC. Because of injuries to Olivier Giroud and Jeremy Ebobisse, they had to move attacker Denis Bouanga to the center instead of out on the wing, which took away from his usual offensive contributions. Getting a tie with Inter Miami brings MLS’ top team right now in at the wrong time.
6. Pumas UNAM
This is a team that has coasted through a favorable draw in the CONCACAF Champions Cup. Beating Canadian Premier League team Cavalry in the round of 32 and Costa Rican side LD Alajuelense was expected, but now they head to Vancouver to take on a team that is playing with house money, on the rise in MLS.
5. Vancouver Whitecaps
The Whitecaps began their MLS season by winning four straight games. Although they have slowed their pace, they eliminated Monterrey in the round of 16 with an alternate team. Midfielder Ryan Gauld is injured, but is expected to return. If they advance to the semifinals, they could spring a surprise.
4. Tigres UANL
Juan Brunetta has six goals in 13 games in Liga MX Clausura play. Tigres will also benefit from having a lot of their own fans when they play at Dignity Health Sports Park. LA Galaxy shouldn’t be a problem for Tigres to get by – but what will happen when they see Club America or Cruz Azul in the semis?
3. Cruz Azul
The quarterfinal tilt with Club America is a significant test. But Cruz Azul have been hot since the calendar turned to 2025. If they can get through, they’d have to be a solid co-favorite to win the whole thing.
2. Club America
This side lead the Clausura standings with 30 points in 13 standings. Victor Davila, Alejandro Zendejas and Alvaro Fidalgo have led the team with five goals, and Luis Angel Malagon has been a brick wall in goal. Club America have seven CONCACAF Champions Cup titles and have the experience and roster to win an eighth.
1. Inter Miami
The Herons beat the only other elite Eastern Conference team in MLS when they stopped Philadelphia, 2-1, this past weekend. Lionel Messi will be back for this trip with his team, although given Inter’s likelihood of stopping LAFC, he may not play. Just having him on the bench will boost his team.
^Epic battles heat up in the Champions Cup ⚔️ pic.twitter.com/CfpoAOmsZ6
— Concacaf Champions Cup (@TheChampions) April 1, 2025
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CONCACAF Champions Cup Odds, Quarterfinals Leg 1 Picks
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